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Science. 2009 Jul 31;325(5940):612-6. doi: 10.1126/science.1175202.

Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

Author information

  • 1Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. fswirski@mgh.harvard.edu

Abstract

A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase their motility, exit the spleen en masse, accumulate in injured tissue, and participate in wound healing. These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.

PMID:
19644120
PMCID:
PMC2803111
DOI:
10.1126/science.1175202
[PubMed - indexed for MEDLINE]
Free PMC Article
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