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Bioorg Med Chem Lett. 2009 Sep 1;19(17):5075-7. doi: 10.1016/j.bmcl.2009.07.042. Epub 2009 Jul 10.

Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues.

Author information

1
New Drug Discovery Research, Department of Medicinal Chemistry, Alwar Pharmacy College, Alwar, Rajasthan, India. asraf80med@rediffmail.com

Abstract

In present investigation, a series of substituted phenyl-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenylmethanone analogues were synthesized and were tested for their potential for treating AD disease. All the newly synthesized compounds were showing moderate to high AChE inhibitory activities, with compound 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4,5-trimethoxyphenylmethanone (5f) produced significant activities with 2.7+/-0.01 micromol/L.

PMID:
19643609
DOI:
10.1016/j.bmcl.2009.07.042
[Indexed for MEDLINE]

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