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Bioorg Med Chem Lett. 2009 Sep 1;19(17):5237-40. doi: 10.1016/j.bmcl.2009.06.104. Epub 2009 Jul 4.

Studies towards topical selective beta2-adrenoceptor agonists with a long duration of action.

Author information

1
Department of Pulmonary Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

Abstract

Beta2-adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The compounds exhibited a high potency in a functional cellular assay and a bronchoprotective effect in a guinea pig model which lasted over the complete study period of 5h.

PMID:
19643607
DOI:
10.1016/j.bmcl.2009.06.104
[Indexed for MEDLINE]

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