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Cancer Lett. 2010 Mar 1;289(1):1-10. doi: 10.1016/j.canlet.2009.04.045. Epub 2009 Jul 29.

Virotherapy against malignant glioma stem cells.

Author information

1
The Brain Tumor Center, The University of Chicago, Chicago, IL, USA.

Abstract

Glioblastoma multiforme, the most common primary intracranial malignancy, is associated with very poor outcome despite advances in surgical techniques and chemo- and radiation therapy. Many novel treatment modalities are being investigated with varying amount of success. Evolution of cancer stem cell hypothesis provides a new venue for developmental therapeutics. In this review, we highlight the literature regarding the existence of glioma stem cells and their characteristics. We also discuss the potential for virotherapy, a novel therapeutic approach utilizing conditionally replicative viruses, to directly target this population of self-renewing cancer stem cells.

PMID:
19643532
PMCID:
PMC2824041
DOI:
10.1016/j.canlet.2009.04.045
[Indexed for MEDLINE]
Free PMC Article

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