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Fertil Steril. 2010 Sep;94(4):1223-8. doi: 10.1016/j.fertnstert.2009.06.049. Epub 2009 Jul 30.

Understanding adenomyosis: a case control study.

Author information

1
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Abstract

OBJECTIVE:

To elucidate the clinical profile of adenomyosis by comparison with uterine leiomyomas.

DESIGN:

Retrospective case-control study.

SETTING:

Academic medical center.

PATIENT(S):

The study comprised 76 women undergoing hysterectomy with adenomyosis and 152 women with uterine leiomyomas but no adenomyosis.

INTERVENTION(S):

Retrospective medical record review of hospital and ambulatory records.

MAIN OUTCOME MEASURE(S):

Comparison of women undergoing hysterectomy with a sole pathologic finding of adenomyosis and women with leiomyomas alone.

RESULT(S):

Adenomyosis was independently associated with younger age (41.1 years vs. 44.3 years), history of depression (57.1% vs. 24.7%), dysmenorrhea (65.7% vs. 42.3%), and pelvic pain (52.9% vs. 21.1%) in a multivariable unconditional logistic regression analysis compared with women with leiomyomas, where women from both groups had gynecologic symptoms. Furthermore, in a second multivariate model where all subjects had uteri weighing>150 g, women with adenomyosis were more likely to have a history of depression (52.6% vs. 22.2%) and endometriosis (26.3% vs. 2.8%) compared with women with leiomyomas.

CONCLUSION(S):

Women undergoing hysterectomy with a histologic diagnosis of adenomyosis have a distinct symptomatology and medical history compared with women with leiomyomas. Better understanding of this disease is required to improve diagnosis and management.

PMID:
19643403
PMCID:
PMC3150965
DOI:
10.1016/j.fertnstert.2009.06.049
[Indexed for MEDLINE]
Free PMC Article

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