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J Nat Prod. 2009 Aug;72(8):1414-8. doi: 10.1021/np9002367.

Synthesis of 3-deoxypentacyclic triterpene derivatives as inhibitors of glycogen phosphorylase.

Author information

1
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, People's Republic of China.

Abstract

The 3-deoxy-2-keto derivatives 5 and 7 of oleanolic acid (1) and ursolic acid (2), respectively, served as precursors to the synthesis of 35 3-deoxy derivatives of pentacyclic triterpenes. The synthesized compounds were biologically assayed for their inhibitory activity against rabbit muscle glycogen phosphorylase a (GPa). Among this series of compounds, 2alpha-hydroxyurs-12-en-28-oic acid (18) (IC(50) = 1.2 microM) exhibited the most potent activity. Preliminary structure-activity relationship analysis for the 3-deoxy triterpene derivatives as GP inhibitors is also discussed.

PMID:
19642687
DOI:
10.1021/np9002367
[Indexed for MEDLINE]

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