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Oncogene. 2008 Dec;27 Suppl 1:S84-92. doi: 10.1038/onc.2009.46.

Noxa: at the tip of the balance between life and death.

Author information

1
Division of Molecular Pathophysiology, Biocenter, Innsbruck Medical University, Innsbruck, Austria.

Abstract

Among all Bcl2 homology domain 3 (BH3)-only proteins known to date, APR/PMAIP1/Noxa, albeit showing weak proapoptotic potential on its own, appears to be crucial in fine-tuning cell death decisions by targeting the prosurvival molecule Mcl1 for proteasomal degradation. This event appears critical for cell death induction along the mitochondrial Bcl2-regulated apoptosis pathway in response to factor deprivation or DNA damage, presumably by sensitizing the cell toward the action of additional BH3-only protein family members. This review aims to summarize the function of Noxa in normal physiology, stress-induced cell death and tumorigenesis.

PMID:
19641509
PMCID:
PMC3272398
DOI:
10.1038/onc.2009.46
[Indexed for MEDLINE]
Free PMC Article

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