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J Dent Res. 2009 Jul;88(7):627-32. doi: 10.1177/0022034509339487.

Cranberry proanthocyanidins inhibit MMP production and activity.

Author information

1
Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Université Laval, 2420 Rue de Terrasse, Quebec City, QC, Canada G1V 0A6.

Abstract

Matrix metalloproteinases (MMPs) produced by resident and inflammatory cells in response to periodontopathogens play a major role in periodontal tissue destruction. Our aim was to investigate the effects of A-type cranberry proanthocyanidins (AC-PACs) on: (i) the production of various MMPs by human monocyte-derived macrophages stimulated with Aggregatibacter actinomycetemcomitans lipopolysaccharide (LPS), and (ii) the catalytic activity of recombinant MMP-1 and MMP-9. The effects of AC-PACs on the expression of 5 protein kinases and the activity of nuclear factor-kappa B (NF-kappaB) p65 in macrophages stimulated with LPS were also monitored. Our results indicated that AC-PACs inhibited the production of MMPs in a concentration-dependent manner. Furthermore, the catalytic activity of MMP-1 and MMP-9 was also inhibited. The inhibition of MMP production was associated with reduced phosphorylation of key intracellular kinases and the inhibition of NF-kappaB p65 activity. AC-PACs thus show potential for the development of novel host-modulating strategies to inhibit MMP-mediated tissue destruction during periodontitis.

PMID:
19641150
DOI:
10.1177/0022034509339487
[Indexed for MEDLINE]

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