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Cytokine. 2009 Sep;47(3):199-205. doi: 10.1016/j.cyto.2009.06.006. Epub 2009 Jul 28.

Human cancer cells have specifically lost the ability to induce the synergistic state caused by tumor necrosis factor plus interferon-beta.

Author information

1
Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, 1600 SW Archer Road, R4-295, Gainesville, FL 32610, USA.

Abstract

Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbeta. Here, we demonstrate that this synergistic state is both antiviral and cytostatic for primary human cells. Significantly, we observed that a wide spectrum of transformed human cancer cells have universally lost the ability to induce the TNF/IFNbeta synergistic state, as defined by three separate criteria. We hypothesize that the ability to induce the TNF/IFNbeta synergistic state is a unique feature of primary cells and is incompatible with cellular immortalization and/or transformation.

PMID:
19640730
PMCID:
PMC4376283
DOI:
10.1016/j.cyto.2009.06.006
[Indexed for MEDLINE]
Free PMC Article

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