Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2009 Sep 1;19(17):4967-70. doi: 10.1016/j.bmcl.2009.07.072. Epub 2009 Jul 18.

Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).

Author information

1
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Abstract

This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. The synthesis takes advantage of an iterative parallel synthesis approach to rapidly synthesize and evaluate a number of analogs of VU0155041.

PMID:
19640716
PMCID:
PMC2752865
DOI:
10.1016/j.bmcl.2009.07.072
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center