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Curr Opin Neurobiol. 2009 Jun;19(3):327-35. doi: 10.1016/j.conb.2009.07.002. Epub 2009 Jul 27.

Dendritic signalling and homeostatic adaptation.

Author information

1
MRC Laboratory for Molecular Cell Biology and MRC Cell Biology Unit, Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.

Abstract

Homeostatic plasticity mechanisms are employed by neurons to alter membrane excitability and synaptic strength to adapt to changes in network activity. Recent studies suggest that homeostatic processes can occur not only on a global scale but also within specific neuronal subcompartments, involving a wide range of molecules and signalling pathways. Here, we review new findings into homeostatic adaptation within dendrites and discuss potential signalling components and mechanisms that may mediate this local form of regulation.

PMID:
19640698
DOI:
10.1016/j.conb.2009.07.002
[Indexed for MEDLINE]

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