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Biol Psychiatry. 2009 Nov 1;66(9):898-901. doi: 10.1016/j.biopsych.2009.06.011. Epub 2009 Jul 29.

Effect of a history of major depressive disorder on smoking-induced dopamine release.

Author information

1
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA. abrody@ucla.edu

Abstract

BACKGROUND:

Dopamine (DA) system dysfunction is implicated in the pathophysiology of major depressive disorder (MDD). We sought to determine if cigarette smokers with a history of MDD and current mild depressive symptoms have abnormal smoking-induced DA release (measured indirectly as change in (11)C-raclopride binding potential [BP(ND)]).

METHODS:

Fifty-six cigarette smokers either with (n = 10) or without (n = 46) a history of MDD (MDD+ and MDD-, respectively) underwent bolus-plus-continuous-infusion (11)C-raclopride positron emission tomography, during which they smoked a regular cigarette. Presmoking to postsmoking changes in (11)C-raclopride BP(ND) were compared between groups. Also, correlations were determined between change in BP(ND) and depression, anxiety, and withdrawal rating scale scores for the MDD+ group.

RESULTS:

The MDD+ group had a significantly greater reduction in (11)C-raclopride BP(ND) (-16.3%) than the MDD- group (-8.4%) (analysis of covariance [ANCOVA], p = .03). Significant negative correlations were found between depression/anxiety and change in (11)C-raclopride BP(ND) (r = -.77, p < .01 and r = -.74, p = .01, respectively).

CONCLUSIONS:

MDD+ smokers have greater smoking-induced DA release than MDD- smokers, and higher depression/anxiety levels are associated with greater smoking-induced DA release. These findings support the theory that MDD+ smokers have DA system dysfunction, including heightened smoking-induced DA release.

PMID:
19640507
PMCID:
PMC2763050
DOI:
10.1016/j.biopsych.2009.06.011
[Indexed for MEDLINE]
Free PMC Article

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