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Neuron. 2009 Jul 30;63(2):216-29. doi: 10.1016/j.neuron.2009.06.010.

Calcium dependence of exo- and endocytotic coupling at a glutamatergic synapse.

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Independent Junior Research Group of Biophysics of Synaptic Transmission, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany.


The mechanism coupling exocytosis and endocytosis remains to be elucidated at central synapses. Here, we show that the mechanism linking these two processes is dependent on microdomain-[Ca2+](i) similar to that which triggers exocytosis, as well as the exocytotic protein synaptobrevin/VAMP. Furthermore, block of endocytosis has a limited, retrograde action on exocytosis, delaying recruitment of release-ready vesicles and enhancing short-term depression. This effect sets in so rapidly that it cannot be explained by the nonavailability of recycled vesicles. Rather, we postulate that perturbation of a step linking exocytosis and endocytosis temporarily prevents new vesicles from docking at specialized sites for exocytosis.

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