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Neuron. 2009 Jul 30;63(2):154-70. doi: 10.1016/j.neuron.2009.06.021.

Activity-dependent regulation of synapses by retrograde messengers.

Author information

1
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA. wade_regehr@hms.harvard.edu

Abstract

Throughout the brain, postsynaptic neurons release substances from their cell bodies and dendrites that regulate the strength of the synapses they receive. Diverse chemical messengers have been implicated in retrograde signaling from postsynaptic neurons to presynaptic boutons. Here, we provide an overview of the signaling systems that lead to rapid changes in synaptic strength. We consider the capabilities, specializations, and physiological roles of each type of signaling system.

PMID:
19640475
PMCID:
PMC3251517
DOI:
10.1016/j.neuron.2009.06.021
[Indexed for MEDLINE]
Free PMC Article

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