Format

Send to

Choose Destination
See comment in PubMed Commons below
Mol Microbiol. 1990 Oct;4(10):1771-7.

Functional similarities between retroviruses and the IS3 family of bacterial insertion sequences?

Author information

1
Centre de Recherche en Biochimie et Génétique, Cellulaire du CNRS, Toulouse, France.

Abstract

Members of the IS3 family of insertion sequences are found in a wide range of bacteria. At least 10 members of this family carry two major open reading frames: a small upstream frame (0 phase), and a longer downstream frame in the -1 phase. The downstream frame shows significant similarity at the amino acid level. A highly conserved region of this frame also exhibits notable similarity with a region of the integrase (endonuclease) domain of retroviruses. Although the overall transposition mechanism of the insertion sequence and retroviral elements is certainly different, the two groups may share additional common features, including a -1 frameshift resulting in the production of a fusion protein.

PMID:
1963920
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center