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J Child Neurol. 2009 Nov;24(11):1409-17. doi: 10.1177/0883073809338960. Epub 2009 Jul 28.

Pediatric high-grade gliomas and diffuse intrinsic pontine gliomas.

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1
Department of Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, IL 60614, USA. jfangusaro@childrensmemorial.org

Abstract

Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.

PMID:
19638636
DOI:
10.1177/0883073809338960
[Indexed for MEDLINE]
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