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Neurosci Lett. 2009 Oct 2;463(2):154-7. doi: 10.1016/j.neulet.2009.07.070. Epub 2009 Jul 26.

Association of verbal and figural creative achievement with polymorphism in the human serotonin transporter gene.

Author information

1
Institute of Physiology of Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia.

Abstract

The purpose of this study was to examine the potential association between the S (short) and L (long) alleles of the 5-HTTLPR polymorphism of the serotonin transporter (5-HTT) gene and verbal and figural creative ability. Sixty-two unrelated Caucasian university students (29 men and 33 women) participated in the experiment. The results showed a significant association between verbal and figural creativity scores and the 5-HTTLPR polymorphism. The subjects with S/S and L/S genotypes demonstrated higher verbal creativity scores in comparison with the L/L genotype carriers. The carriers of S/S genotype demonstrated also higher figural creativity scores in comparison with the carries of L/S and L/L genotypes. Thus, it is the first report on a significant association between the 5-HTTLPR polymorphism and creative achievements. As the 5-HTTLPR polymorphism is associated with genetically defined alteration in the brain serotonergic neurotransmission our result provides an evidence of the involvement of the central serotonin system in creativity regulation.

PMID:
19638296
DOI:
10.1016/j.neulet.2009.07.070
[Indexed for MEDLINE]

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