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Org Lett. 2009 Aug 20;11(16):3523-5. doi: 10.1021/ol901325s.

Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate.

Author information

1
Pfizer Global Research & Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA. marVin.j.meyers@pfizer.com

Abstract

Two efficient and scaleable synthetic routes to previously unknown bifunctional tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate are described. This compound and related intermediates described herein are useful for further selective derivation on the azetidine and cyclobutane rings providing a convenient entry point to novel compounds accessing chemical space complementary to piperidine ring systems.

PMID:
19637855
DOI:
10.1021/ol901325s
[Indexed for MEDLINE]

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