Send to

Choose Destination
See comment in PubMed Commons below
Eur J Immunol. 2009 Aug;39(8):2065-75. doi: 10.1002/eji.200939531.

Memory B cells: effectors of long-lived immune responses.

Author information

Immunology and Inflammation Department, Garvan Institute of Medical Research, NSW, Australia.

Erratum in

  • Eur J Immunol. 2010 Jan;40(1):302.


Immunological memory is the phenomenon whereby B and T cells have the unique ability to respond with heightened kinetics and efficacy to subsequent encounter with Ag relative to the initial exposure. In this review, we examine recent developments in the phenotypic characterisation of memory B cells, with an emphasis on the definition and functional properties of memory B-cell subsets in humans. Gene expression differences are also considered in light of the unique functional and survival properties of memory B cells, and mutations that alter memory formation and function are also examined. Finally, we consider recent advances in the understanding of germinal center B-cell differentiation through analysis of transcription factor networks operating in these B cells.

[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center