Format

Send to

Choose Destination
Eur J Immunol. 2009 Aug;39(8):2059-64. doi: 10.1002/eji.200939435.

Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?

Author information

1
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0414, USA.

Abstract

Since their discovery three decades ago, NK cells have been classified as cells of the innate immune system. NK cells were shown to respond rapidly and non-specifically to infection, and were thought to act as a functional "bridge" to sustain the early innate immune response until the later adaptive immune responses could be mounted. In light of new findings showing how NK cells possess nearly all of the features of adaptive immunity including memory, we propose the placement of NK cells as an "evolutionary bridge" between innate and adaptive immunity.

PMID:
19637199
PMCID:
PMC2819266
DOI:
10.1002/eji.200939435
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center