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Am J Drug Alcohol Abuse. 2009;35(5):316-9. doi: 10.1080/00952990903060150.

The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers.

Author information

1
Boston University School of Medicine, Massachusetts, USA.

Abstract

OBJECTIVE:

The purpose of this study is to examine the effects of zonisamide on ethanol self-administration and subjective effects in risky drinkers using a human laboratory paradigm.

METHOD:

We conducted a double-blind, placebo-controlled study of the effects of zonisamide 100 mg on ethanol self-administration and urge to drink in risky drinkers (N = 10) ( [1] ).

RESULT:

During the second hour of a 2-hour self-administration session ethanol consumption was 50% lower in the zonisamide group as compared to the placebo group. Urge to drink was also significantly lower under the zonisamide condition.

CONCLUSION:

These results indicate that a single dose of zonisamide reduces urge to drink and the quantity of ethanol self-administered by risky drinkers during their second hour of access to alcohol.

SCIENTIFIC SIGNIFICANCE:

Zonisamide may help individuals drinking at risky levels reduce their intake of alcohol.

PMID:
19637104
PMCID:
PMC4028067
DOI:
10.1080/00952990903060150
[Indexed for MEDLINE]
Free PMC Article

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