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Lab Chip. 2009 Aug 21;9(16):2281-5. doi: 10.1039/b907430a. Epub 2009 Jun 17.

An integrated microfluidic device for large-scale in situ click chemistry screening.

Author information

1
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 570 Westwood Plaza, building 114, Los Angeles, CA 90095, USA.

Abstract

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

PMID:
19636457
PMCID:
PMC2878189
DOI:
10.1039/b907430a
[Indexed for MEDLINE]
Free PMC Article

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