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PLoS One. 2009 Jul 28;4(7):e6402. doi: 10.1371/journal.pone.0006402.

2009 Swine-origin influenza A (H1N1) resembles previous influenza isolates.

Author information

1
Center for Bioinformatics and Computational Biology, Institute for Advance Computer Studies, University of Maryland, College Park, Maryland, United States of America. carlk@umiacs.umd.edu

Abstract

BACKGROUND:

In April 2009, novel swine-origin influenza viruses (S-OIV) were identified in patients from Mexico and the United States. The viruses were genetically characterized as a novel influenza A (H1N1) strain originating in swine, and within a very short time the S-OIV strain spread across the globe via human-to-human contact.

METHODOLOGY:

We conducted a comprehensive computational search of all available sequences of the surface proteins of H1N1 swine influenza isolates and found that a similar strain to S-OIV appeared in Thailand in 2000. The earlier isolates caused infections in pigs but only one sequenced human case, A/Thailand/271/2005 (H1N1).

SIGNIFICANCE:

Differences between the Thai cases and S-OIV may help shed light on the ability of the current outbreak strain to spread rapidly among humans.

PMID:
19636415
PMCID:
PMC2712239
DOI:
10.1371/journal.pone.0006402
[Indexed for MEDLINE]
Free PMC Article
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