Format

Send to

Choose Destination
J Math Biol. 2010 May;60(5):687-710. doi: 10.1007/s00285-009-0282-7. Epub 2009 Jul 25.

Relating recent infection prevalence to incidence with a sub-population of assay non-progressors.

Author information

1
School of Computational and Applied Mathematics, University of the Witwatersrand, Johannesburg, South Africa.

Abstract

We present a new analysis of relationships between disease incidence and the prevalence of an experimentally defined state of 'recent infection'. This leads to a clean separation between biological parameters (properties of disease progression as reflected in a test for recent infection), which need to be calibrated, and epidemiological state variables, which are estimated in a cross-sectional survey. The framework takes into account the possibility that details of the assay and host/pathogen chemistry leave a (knowable) fraction of the population in the recent category for all times. This systematically addresses an issue which is the source of some controversy about the appropriate use of the BED assay for defining recent HIV infection. The analysis is, however, applicable to any assay that forms the basis of a test for recent infection. Analysis of relative contributions of error arising variously from statistical considerations and simplifications of general expressions indicate that statistical error dominates heavily over methodological bias for realistic epidemiological and biological scenarios.

PMID:
19633851
DOI:
10.1007/s00285-009-0282-7
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center