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J Bacteriol. 2009 Nov;191(22):7121-2. doi: 10.1128/JB.00845-09. Epub 2009 Jul 24.

Cyclic di-GMP allosterically inhibits the CRP-like protein (Clp) of Xanthomonas axonopodis pv. citri.

Author information

1
Department of Bacteriology, 1550 Linden Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.

Abstract

The protein Clp from Xanthomonas axonopodis pv. citri regulates pathogenesis and is a member of the CRP (cyclic AMP receptor protein) superfamily. We show that unlike the DNA-binding activity of other members of this family, the DNA-binding activity of Clp is allosterically inhibited by its effector and that cyclic di-GMP serves as that effector at physiological concentrations.

PMID:
19633082
PMCID:
PMC2772467
DOI:
10.1128/JB.00845-09
[Indexed for MEDLINE]
Free PMC Article

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