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Curr Opin Microbiol. 2009 Aug;12(4):453-9. doi: 10.1016/j.mib.2009.06.004. Epub 2009 Jul 24.

Connecting viral with cellular interactomes.

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Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universit√§t M√ľnchen, Muenchen, Germany.


Genome-scale screens for intraviral and virus-host protein interactions and the analysis of literature-curated datasets are able to provide a novel, comprehensive perspective of viruses, and virus-infected cells. Until now, large-scale interaction screens were predominantly performed with the yeast-two-hybrid (Y2H) system; however, alternative high-throughput technologies detecting binary protein interactions or protein complexes have been developed. Although many of the previous studies suffer from a rather poor validation of the results and few biological implications, these technologies potentially lead to a plethora of novel hypotheses. Here, we will give an overview of current approaches and their technical limitations, present recent examples and novel developments.

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