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Cell. 2009 Jul 23;138(2):233-44. doi: 10.1016/j.cell.2009.07.002.

Evolution of transcriptional regulatory circuits in bacteria.

Author information

1
Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, Campus Box 8230, 660 S. Euclid Avenue, St. Louis, MO 63110, USA.

Abstract

Related organisms typically respond to a given cue by altering the level or activity of orthologous transcription factors, which, paradoxically, often regulate expression of distinct gene sets. Although promoter rewiring of shared genes is primarily responsible for regulatory differences among related eukaryotic species, in bacteria, species-specific genes are often controlled by ancestral transcription factors, and regulatory circuit evolution has been further shaped by horizontal gene transfer. Modifications in transcription factors and in promoter structure also contribute to divergence in bacterial regulatory circuits.

PMID:
19632175
PMCID:
PMC2726713
DOI:
10.1016/j.cell.2009.07.002
[Indexed for MEDLINE]
Free PMC Article

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