Send to

Choose Destination
Curr Opin Microbiol. 2009 Aug;12(4):365-70. doi: 10.1016/j.mib.2009.05.006. Epub 2009 Jul 23.

How human pathogenic fungi sense and adapt to pH: the link to virulence.

Author information

1360 Mayo Building MMC196, Department of Microbiology, University of Minnesota, Minneapolis, MN 55455, USA.


The ability of fungal pathogens to cause disease is dependent on the ability to grow within the human host environment. In general, the human host environment can be considered a slightly alkaline environment, and the ability of fungi to grow at this pH is essential for pathogenesis. The Rim101 signal transduction pathway is the primary pH sensing pathway described in the pathogenic fungi, and in Candida albicans, it is required for a variety of diseases. As more detailed analyses have been conducted studying pathogenesis at the molecular level, it has become clear that the Rim101 pathway, and pH responses in general, play an intimate role in pathogenesis beyond simply allowing the organism to grow. Here, several recent advances into Rim101-dependent functions implicated in disease progression are discussed.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center