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Eur J Pharmacol. 1990 Sep 21;186(2-3):343-7.

Inhibition of electrically evoked contractions of guinea-pig ileum preparations mediated by the histamine H3 receptor.

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1
Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.

Abstract

We investigated the contraction responses of isolated guinea-pig ileum preparations under several conditions of electrical field stimulation. Histamine H3-agonists caused a dose-dependent inhibition of both cholinergic and nonadrenergic noncholinergic (NANC) responses (pD2 of histamine, 7.3; N alpha-methylhistamine, 8.4; (R)-alpha-methylhistamine, 8.3); H3-antagonists blocked this inhibition (pA2 of impromidine, 7.2; thioperamide, 8.5). Our results indicate that H3-receptors are present on both cholinergic and NANC nerves in the myenteric plexus and that the preparation can be used as a rapid and simple test system for histamine H3-receptors.

PMID:
1963151
[Indexed for MEDLINE]
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