Format

Send to

Choose Destination
J Med Chem. 2009 Aug 27;52(16):5241-52. doi: 10.1021/jm900736e.

Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.

Author information

1
Respiratory CEDD, GlaxoSmithKline, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939, USA. dramane.i.laine@gsk.com

Abstract

Novel tropane derivatives were characterized as muscarinic acetylcholine receptor antagonists (mAChRs). Through optimization of the structure-activity relationship around the tropane scaffold, the quaternary ammonium salt 34 was identified as a very potent M(3) mAChR antagonist. The compound was functionally active and displayed greater than 24 h duration of action in a mouse model of bronchoconstriction.

PMID:
19630384
DOI:
10.1021/jm900736e
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center