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J Magn Reson Imaging. 2009 Aug;30(2):374-83. doi: 10.1002/jmri.21845.

Evaluating the role of zinc in the occurrence of fibrosis of the skin: a preclinical study.

Author information

1
Contrast Media Research, Bayer Schering Pharma AG, Berlin, Germany.

Abstract

PURPOSE:

To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium-based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF).

MATERIALS AND METHODS:

In the Zn supplementation study, rats were injected with Gadodiamide, Omniscan, and Magnevist with or without Zn supplementation. In the Zn depletion study, animals were kept on a Zn-deficient diet or a special control diet and received injections of Omniscan, OptiMARK, Magnevist, Gadovist, and Gd-EDTA. Gd, Zn, and Cu concentrations in tissue were measured and histology of the skin was performed.

RESULTS:

As seen in earlier studies, a difference in Gd concentration in the skin was observed following treatment with the different GBCAs. High Gd concentration in the skin correlated with the occurrence of NSF-like skin lesions. We observed no differences in the occurrence of skin lesions between the Zn supplementation and the Zn-deficient groups compared to their respective control groups.

CONCLUSION:

We found no significant effect of Zn on the initiation of NSF-like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs.

PMID:
19629978
DOI:
10.1002/jmri.21845
[Indexed for MEDLINE]

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