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Mamm Genome. 2009 Jul;20(7):395-403. doi: 10.1007/s00335-009-9204-7. Epub 2009 Jul 21.

The gastrointestinal microbiome: a malleable, third genome of mammals.

Author information

1
Department of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

The nonpathogenic, mutualistic bacteria of the mammalian gastrointestinal tract provide a number of benefits to the host. Recent reports have shown how the aggregate genomes of gastrointestinal bacteria provide novel benefits by functioning as the third major genome in mammals along with the nuclear and mitochondrial genomes. Consequently, efforts are underway to elucidate the complexity of the organisms comprising the unique ecosystem of the gastrointestinal tract, as well as those associated with other epidermal surfaces. The current knowledge of the gastrointestinal microbiome, its relationship to human health and disease with a particular focus on mammalian physiology, and efforts to alter its composition as a novel therapeutic approach are reviewed.

PMID:
19629594
PMCID:
PMC4372805
DOI:
10.1007/s00335-009-9204-7
[Indexed for MEDLINE]
Free PMC Article

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