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Biol Trace Elem Res. 2010 May;134(2):119-29. doi: 10.1007/s12011-009-8465-z. Epub 2009 Jul 24.

Implications of magnesium deficiency in type 2 diabetes: a review.

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Department of Plant Breeding and Genetics, Punjab Agricultural University, Ludhiana 141004, India.


Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. It plays a fundamental role as a cofactor in various enzymatic reactions involving energy metabolism. Magnesium is a cofactor of various enzymes in carbohydrate oxidation and plays an important role in glucose transporting mechanism of the cell membrane. It is also involved in insulin secretion, binding, and activity. Magnesium deficiency and hypomagnesemia can result from a wide variety of causes, including deficient magnesium intake, gastrointestinal, and renal losses. Chronic magnesium deficiency has been associated with the development of insulin resistance. The present review discusses the implications of magnesium deficiency in type 2 diabetes.

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