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Bioorg Med Chem Lett. 2009 Sep 1;19(17):5225-8. doi: 10.1016/j.bmcl.2009.07.007. Epub 2009 Jul 8.

Benzo[c][2,7]naphthyridines as inhibitors of PDK-1.

Author information

1
Wyeth Research, Chemical Sciences, 401 N. Middletown Road, Pearl River, NY 10965, USA. kimk@wyeth.com

Abstract

A series of substituted benzo[c][2,7]-naphthyridines were prepared and showed good potency in inhibiting PDK-1. The synthesis and SAR of this series of compounds are presented as well as the X-ray crystal structure of one of these analogs in a complex with PDK-1.

PMID:
19628388
DOI:
10.1016/j.bmcl.2009.07.007
[Indexed for MEDLINE]

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