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FEBS Lett. 2009 Aug 20;583(16):2663-73. doi: 10.1016/j.febslet.2009.07.031. Epub 2009 Jul 20.

Animal models of human amyloidoses: are transgenic mice worth the time and trouble?

Author information

1
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA. jbux@scripps.edu

Abstract

The amyloidoses are the prototype gain of toxic function protein misfolding diseases. As such, several naturally occurring animal models and their inducible variants provided some of the first insights into these disorders of protein aggregation. With greater analytic knowledge and the increasing flexibility of transgenic and gene knockout technology, new models have been generated allowing the interrogation of phenomena that have not been approachable in more reductionist systems, i.e. behavioral readouts in the neurodegenerative diseases, interactions among organ systems in the transthyretin amyloidoses and taking pre-clinical therapeutic trials beyond cell culture. The current review describes the features of both transgenic and non-transgenic models and discusses issues that appear to be unresolved even when viewed in their organismal context.

PMID:
19627988
PMCID:
PMC2749068
DOI:
10.1016/j.febslet.2009.07.031
[Indexed for MEDLINE]
Free PMC Article

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