Format

Send to

Choose Destination
BMC Dev Biol. 2009 Jul 23;9:43. doi: 10.1186/1471-213X-9-43.

YA is needed for proper nuclear organization to transition between meiosis and mitosis in Drosophila.

Author information

1
Dept of Molecular Biology and Genetics, Cornell University, Ithaca NY 14853, USA. klb56@cornell.edu

Abstract

BACKGROUND:

The Drosophila YA protein is required to initiate the embryonic cleavage divisions. After egg activation, YA enters nuclei and interacts with chromatin and the nuclear lamina. This study was designed to define more precisely the events prior to the first cleavage division that are dependent upon YA.

RESULTS:

We find that meiosis is completed normally in the absence of YA function. The first defects in embryos and eggs from mutant mothers first appear just after the completion of meiosis, and are seen as abnormal associations among the resultant haploid nuclei. These defects are associated with asynchronies in the cell cycle-dependent chromatin condensation state of the haploid nuclei. However, we find evidence of DNA replication in the absence of YA function.

CONCLUSION:

Our data suggest YA function is needed at a control point, following meiosis II and the initiation of the first postmeiotic S phase, which is sensitive to the chromatin condensation state of the haploid meiotic products.

PMID:
19627584
PMCID:
PMC2724486
DOI:
10.1186/1471-213X-9-43
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center