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Neuropsychol Rehabil. 2009 Dec;19(6):891-903. doi: 10.1080/09602010903091066. Epub 2009 Jul 16.

Efficient translational rehabilitation randomised controlled trial designs using disease progress modelling and trial simulation.

Author information

1
Institute of Neuroscience, Newcastle University, UK. r.j.forsyth@newcastle.ac.uk

Abstract

Given the challenges inherent in randomised trials of rehabilitation interventions, methods are required to increase trial efficiency and information yield. This paper discusses, in a non-technical manner, a class of statistical models that is particularly suited to the task of detecting potential treatment effects against a background of spontaneous change.

PMID:
19626555
DOI:
10.1080/09602010903091066
[Indexed for MEDLINE]

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