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J Immunol. 2009 Aug 15;183(4):2435-43. doi: 10.4049/jimmunol.0900568. Epub 2009 Jul 22.

IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells.

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1
Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Although the physiologic pathways that control regulatory T cells (Foxp3-expressing regulatory T cells, IL-10-secreting Tr1 cells) and Th17 cells in rodents have been defined, the factors that control these differentiation pathways in humans are not well understood. In this study, we show that IL-27 promotes the differentiation of IL-10-secreting Tr1 cells while inhibiting Th17 generation and molecules associated with Th17 function. Furthermore, IL-27 inhibits IL-17-polarizing cytokines on dendritic cells, which in turn decrease IL-17 secretion from T cells. Our results demonstrate that IL-27 plays a key role in human T cells by promoting IL-10-secreting Tr1 cells and inhibiting Th17 cells and thus provides a dual regulatory mechanism to control autoimmunity and tissue inflammation.

PMID:
19625647
PMCID:
PMC2904948
DOI:
10.4049/jimmunol.0900568
[Indexed for MEDLINE]
Free PMC Article
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