Format

Send to

Choose Destination
See comment in PubMed Commons below
J Neurosci. 2009 Jul 22;29(29):9219-26. doi: 10.1523/JNEUROSCI.5667-08.2009.

Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation.

Author information

1
Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel.

Abstract

We aimed to test whether tyrosine phosphorylation of the NMDA receptor (NMDAR) in the insular cortex is necessary for novel taste learning. We found that in rats, novel taste learning leads to elevated phosphorylation of tyrosine 1472 of the NR2B subunit of the NMDAR and increases the interaction of phosphorylated NR2B with the major postsynaptic scaffold protein PSD-95. Injection of the tyrosine kinase inhibitor genistein directly into the insular cortex of rats before novel taste exposure prevented the increase in NR2B tyrosine phosphorylation and behaviorally attenuated taste-memory formation. Functionally, tyrosine phosphorylation of NR2B after learning was found to determine the synaptic distribution of the NMDAR, since microinjection of genistein to the insular cortex altered the distribution pattern of NMDAR caused by novel taste learning.

PMID:
19625512
DOI:
10.1523/JNEUROSCI.5667-08.2009
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center