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Chem Soc Rev. 2009 Aug;38(8):2360-84. doi: 10.1039/b813796j. Epub 2009 Jun 15.

Nanopore analytics: sensing of single molecules.

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Department of Chemistry, Institute of Structural Molecular Biology, University College London, London, UK WC1H 0AJ.


In nanopore analytics, individual molecules pass through a single nanopore giving rise to detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore analytics has gained popularity and can be conducted with natural protein as well as man-made polymeric and inorganic pores. The spectrum of detectable analytes ranges from nucleic acids, peptides, proteins, and biomolecular complexes to organic polymers and small molecules. Apart from being an analytical tool, nanopores have developed into a general platform technology to investigate the biophysics, physicochemistry, and chemistry of individual molecules (critical review, 310 references).

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