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Nat Immunol. 2009 Aug;10(8):817-21. doi: 10.1038/ni.1776. Epub 2009 Jul 21.

RAG: a recombinase diversified.

Author information

1
Howard Hughes Medical Institute, Department of Biology, Cambridge, Massachusetts, USA. adamgm@mit.edu.

Abstract

During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination. In the past 20 years, a great deal has been learned about the enzymatic activities of the RAG-1-RAG-2 complex. Recent studies have identified several new and exciting regulatory functions of the RAG-1-RAG-2 complex. Here we discuss some of these functions and suggest that the RAG-1-RAG-2 complex nucleates a specialized subnuclear compartment that we call the 'V(D)J recombination factory'.

PMID:
19621044
PMCID:
PMC3773180
DOI:
10.1038/ni.1776
[Indexed for MEDLINE]
Free PMC Article

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