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Int J Gynecol Pathol. 2009 May;28(3):239-55. doi: 10.1097/PGP.0b013e31818d8fe6.

DNA mismatch repair deficiency in endometrial carcinoma.

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Department of Pathology and Laboratory Medicine, University of California Irvine, Orange, California, USA.


Microsatellite instability (MSI) is the hallmark of a molecular pathway to carcinogenesis due to sporadic or inherited abnormalities of DNA mismatch repair genes. Inherited mutations are seen in hereditary nonpolyposis colorectal cancer syndrome. Endometrial carcinoma shows as high an incidence of MSI as does colorectal carcinoma. This review provides a framework for the gynecologic pathologist to understand the complexities of MSI in endometrial carcinoma, by discussing the basic mechanisms of mismatch repair and carcinogenesis, testing, the morphologic features of MSI endometrial cancer and the contradictory data regarding prognosis.

[Indexed for MEDLINE]

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