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Res Microbiol. 2009 Sep;160(7):487-92. doi: 10.1016/j.resmic.2009.07.004. Epub 2009 Jul 18.

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery.

Author information

1
The Department of Structural Biology, Weizmann Institute, Rehovot, Israel.

Abstract

Structural analysis supported by biochemical, mutagenesis and computational evidence, revealed that the contemporary ribosome's active site is a universal symmetrical pocket made of ribosomal RNA. This pocket seems to be the remnant of the proto-ribosome, a dimeric RNA assembly evolved by gene duplication, capable of autonomously catalyzing peptide bond formation and non-coded amino acid polymerization.

PMID:
19619641
DOI:
10.1016/j.resmic.2009.07.004
[Indexed for MEDLINE]

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