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Dev Cell. 2009 Jul;17(1):27-34. doi: 10.1016/j.devcel.2009.07.002.

A new look at TCF and beta-catenin through the lens of a divergent C. elegans Wnt pathway.

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  • 1Department of Biochemistry and Howard Hughes Medical Institute, University of Wisconsin-Madison, Madison, WI 53706-1544, USA.


The canonical Wnt/beta-catenin pathway is extensively characterized, broadly conserved, and clinically important. In this review, we describe the C. elegans Wnt/beta-catenin asymmetry pathway and suggest that some of its unusual features may have important implications for the canonical Wnt/beta-catenin pathway.

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