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Biomed Environ Sci. 2009 Apr;22(2):136-40. doi: 10.1016/S0895-3988(09)60036-2.

Characterization of Salmonella enterica serotype typhimurium from outpatients of 28 hospitals in Henan province in 2006.

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  • 1Huaxi School of Public Health, Sichuan University, Chengdu 610041, Sichuan, China.

Abstract

OBJECTIVE:

To characterize the diarrheal patients with Salmonella typhimurium (S. typhimurium) infections and to set up the first baseline for S. typhimurium pulsed-field gel electrophoresis (PFGE) patterns in Henan province, thus laying a foundation for comprehensive surveillance of Salmonella in human as well as foods.

METHODS:

S. typhimurium isolates recovered from outpatients with diarrhea in Henan province from May to October of 2006 were characterized. Antimicrobial susceptibility tests of 8 antimicrobial agents and PFGE were carried out to analyze the S. typhimurium isolates.

RESULTS:

Twenty-four (0.9%) S. typhimurium isolates were identified from 2661 stool specimens of diarrheal cases. Eighty-eight percent of isolates showed resistance to at least one antimicrobial agent. The resistance to chloramphenicol (79%) was most common. Fifty-eight percent of isolates were resistant to ciprofloxacin. All the 14 ciprofloxacin-resistant isolates were resistant to more than five antimicrobial agents. Thirty-three percent of S. typhimurium isolates were resistant to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline (R-type ACSSuT). Eight antimicrobia-resistant phenotypes were found among the 24 isolates in 16 PFGE patterns.

CONCLUSION:

The rate of multidrug-resistant S. typhimurium is relatively high in S. typhimurium PFGE patterns of Henan province. Multidrug-resistant S. typhimurium should be considered a public health threat.

PMID:
19618691
DOI:
10.1016/S0895-3988(09)60036-2
[PubMed - indexed for MEDLINE]
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