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Pediatr Blood Cancer. 2009 Dec;53(6):1136-9. doi: 10.1002/pbc.22142.

WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

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1
Division of Pediatric Oncology, Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland 21231, USA.

Abstract

WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these studies have been relatively small. WT1 expression was measured by quantitative RT-PCR in samples obtained at diagnosis from 155 pediatric AML patients treated on a cooperative group protocol. Neither overall survival nor event-free survival was correlated with WT1 expression.

PMID:
19618455
PMCID:
PMC2926132
DOI:
10.1002/pbc.22142
[Indexed for MEDLINE]
Free PMC Article
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