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Pharmacology. 1991;43(1):36-46.

Dietary modulation of cytochrome P450 in the small intestinal epithelium.

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Department of Metabolism/Pharmacology, Rockefeller University, New York, N.Y.


Cytochrome P450 function was compared in rats maintained on cereal-based chow or a purified diet that simulates nutrient levels present in the chow. Ethoxycoumarin O-deethylase activity was increased in small intestine (15-fold), colon (2.5-fold) and liver (1.6-fold) by cereal chow. Ethoxyresorufin O-deethylase activity was also increased by cereal chow (75- and 2.5-fold in small intestine and liver, respectively). Cytochrome P450IAI, detected by Western blotting, was observed in intestinal microsomes isolated from chow-fed rats. These data underscore the importance of dietary considerations when evaluating studies of xenobiotics that undergo 'first pass' cytochrome P450-dependent metabolism in the small intestine.

[Indexed for MEDLINE]

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