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Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10510-4.

GAL4 is phosphorylated as a consequence of transcriptional activation.

Author information

1
Department of Biochemistry, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Abstract

GAL4 protein isolated from yeast in which it is active is phosphorylated predominantly on two different serine residues. One of these was identified as Ser-837; substitution of this residue for alanine has no detectable effect on transcriptional activation by GAL4. Phosphorylation at Ser-837 requires that both the DNA binding and transcriptional activation functions be intact. We propose that some phosphorylations of GAL4, including that at Ser-837, occur concomitantly with activation of transcription.

PMID:
1961715
PMCID:
PMC52958
[Indexed for MEDLINE]
Free PMC Article

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