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Bioorg Med Chem. 2009 Aug 15;17(16):5962-7. doi: 10.1016/j.bmc.2009.06.068. Epub 2009 Jul 3.

Design, synthesis, and structure-activity relationships of 1,3-dihydrobenzimidazol-2-one analogues as anti-HIV agents.

Author information

1
Dipartimento Farmaco-Chimico, Università di Messina, Italy. ammonforte@pharma.unime.it

Abstract

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have become very important components in the antiretroviral combination therapies used to treat HIV. Recently, our group identified some 1,3-dihydrobenzimidazol-2-one derivatives and their sulfones as a potent and novel class of NNRTIs. We herein report the synthesis and biological evaluation of the new compounds in which different structural modifications have been introduced in order to investigate their effects on RT inhibition.

PMID:
19616956
DOI:
10.1016/j.bmc.2009.06.068
[Indexed for MEDLINE]

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