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Cell Host Microbe. 2009 Jul 23;6(1):10-21. doi: 10.1016/j.chom.2009.06.007.

Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

Abstract

The dominant conceptual framework for understanding innate immunity has been that host cells respond to evolutionarily conserved molecular features of pathogens called pathogen-associated molecular patterns (PAMPs). Here, we propose that PAMPs should be understood in the context of how they are naturally presented by pathogens. This can be experimentally challenging, since pathogens, almost by definition, bypass host defense. Nevertheless, in this review, we explore the idea that the immune system responds to PAMPs in the context of additional signals that derive from common "patterns of pathogenesis" employed by pathogens to infect, multiply within, and spread among their hosts.

PMID:
19616762
PMCID:
PMC2777727
DOI:
10.1016/j.chom.2009.06.007
[Indexed for MEDLINE]
Free PMC Article

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